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KMID : 0384119930130040699
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 4 p.699 ~ p.706
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Utility of a Lamellar Body Count Using Coulter STKR Cell Counter in the Assessment of Fetal Lung Maturity
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서을주
김미나/민원기/지현숙/이인식/이영아/구홍회
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Abstract
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Lamellar bodies are surfactant-containing, lamellated structures, secreted during fetal development from type II pneumocytes into amniotic fluid, and the count is increasing with fetal lung maturity. A rapid determination of amniotic fluid
lamellar
body
count using electronic particle counter has recently been shown to be useful for the assessment of fetal lung maturity. The authors have evaluated the reproducibility and linearity of lamellar body count using Coulter STKR cell counter and
compared
the
result of this method with lecithin/sphingomyelin(L/S) ratio in predicting the clinical outcome in 112 cases of neonates including 5 cases of hyaline membrane disease. The reproducibility (CV:2.4-3.4%) and linearity(r=0.99) were considered
acceptable.
Both lamellar body count and L/S ratio showed good correlation with the clinical outcome, however the correlation between two methods was poor(r=0.304). With a cutoff value of 20,000/μL for the lamellar body count, the sensitivity and
specificity
were
100% and 95.3%, respectively, which were comparable to those of L/S ratio with a cutoff value of 2.0 Determination of the lamellar body count using cell counter appears to be a rapid, simple, inexpensive and sensitive screening method for the
assessment
of fetal lung maturity.
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KEYWORD
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